Sunday, September 16, 2012

Should I become a teacher?.the economics - Jeff Piontek

Fortuitously, in the midst of the contentiousChicago teachers union strike, the Organization for Economic Cooperation and Development has released its?annual reporton the state of education and investment in education around the developed world. It might help provide some context for what Chicago teachers are fighting over.

Here?s one particularly striking figure from the report, showing the ratio of teacher salaries to the earnings of other workers who went to college:

Source: Organization for Economic Cooperation and Development.

The United States spends a lot of money on education; including both public and private spending, America spends 7.3 percent of its gross domestic product on all levels of education combined. That?s above the average for the O.E.C.D., where the share is 6.2 percent.

The annual spending per student by educational institutions of all levels is also higher in the United States than it is in any other developed country.

Despite the considerable amount of money channeled into education here, teaching jobs in the United States are not as well paid as they are abroad, at least when you consider the other opportunities available to teachers in each country.

In most rich countries, teachers earn less, on average, than other workers who have college degrees. But the gap is much wider in the United States than in most of the rest of the developed world.

The average primary-school teacher in the United States earns about 67 percent of the salary of a average college-educated worker in the United States. The comparable figure is 82 percent across the overall O.E.C.D. For teachers in lower secondary school (roughly the years Americans would call middle school), the ratio in the United States is 69 percent, compared to 85 percent across the O.E.C.D. The average upper secondary teacher earns 72 percent of the salary for the average college-educated worker in the United States, compared to 90 percent for the overall O.E.C.D.

American teachers, by the way, spend a lot more time teaching than do their counterparts in most other developed countries:

Source: Organization for Economic Cooperation and Development. Year of reference for Argentina is 2009. Numbers for the United States, England, Denmark, Japan, Indonesia and the Russian Federation refer to actual teaching hours.

So tell me: Given the opportunity costs of becoming a teacher instead of using your college degree to enter another, more remunerative field, are the psychic rewards of teaching great enough to convince America?s best and brightest to become educators?

?

Original post by?CATHERINE RAMPELL

Source: http://jeffpiontek.com/2012/09/14/should-i-become-a-teacher-the-economics/

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Ebay pushing an 'update' to previous version of the app, v2.0 has been recalled

Android Central

The official eBay app recieved a much needed update just a few days ago, bringing a much improved visual experience and some new features depending on where you are in the world. Now though, v2.0 has been recalled, and replaced with an 'update' to the previous version of the app, which is now live in Google Play. There isn't much clue as to what the issues may have been -- unless you experienced them personally -- as eBay is being a little vague at this time. Whatever it is, must be something pretty big. Opening the application now greets you with a message as we see here, and has been accompanied by an email from eBay which dropped into our inbox this morning. 

By now, you have probably noticed that we experienced an issue with the latest version of our Android app. As a result, we have temporarily replaced the latest version with the previous one. We value our customers and regret any inconvenience. Delivering the very best shopping experiences to our customers is our goal – anywhere, anytime and on any device.

Thank you,

eBay Mobile Team

So, there's no choice in the matter, even if it worked perfectly OK for you. To carry on using eBay on your Android Device head on over to the Play Store and grab the latest -- and previous -- version. In the meantime, what issues did you guys see? Sing out in the comments below and share with us all. 



Source: http://feedproxy.google.com/~r/androidcentral/~3/JToAvGm2QuM/story01.htm

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NJ Chapter, September Breakfast Meeting Recap - Fishnet Business ...

The Jersey Shore, NJ FISHNET Chapter?s monthly business networking breakfast meeting was such a success yesterday morning.

The meeting was run by Tasha from Viridian and the group introduced themselves and their businesses to two new members. The new members being welcomed to FISHNET were Donna Knepper from Hearts Desire Hair Design in Bradley Beach, NJ and Lisa Mazzuca from On Your Mark Design and Graphics in Beachwood, NJ.

A few members gave extended introductions about their business including Terry Riccardelli from ParyLite who told us about new fall products, the scent of the month is Mahogany Apple, and informed us that she holds the honor of being the consultant who?s been with the company the 2nd longest! She also let us know why you should trim the wicks on your candles.

Tasha Peslak from Viridian gave us information about saving money by switching your electricity and gas provider to Viridian, a greener and more environmentally conscious company. Once you do, you will see your savings appear on your regular monthly bill, it?s so easy to switch!

Charlie from Caswell Plumbing, Heating & Remodeling in Toms River (732-270-0662) told us about the benefits of installing new high energy efficient equipment, such as furnaces, hot water heaters, AC units and more. in your home and the cost savings involved. Tasha vouched for these savings by describing the difference in her energy bills after she moved from a smaller house with older equipment to newer construction with energy efficient models.

Gerry LaBruzza from Guardian Pest Control (732-278-2148) gave us all a lesson in the prevalence of bed bugs in NJ and spoke about the effective heat technology his company uses to eradicate them from homes and businesses. He also gave us all step by step advice on what to look for do when traveling and what to do if we do find evidence so we don?t bring them back into our homes.

To close the meeting, Lisa Mazzuca, social media manager and owner of On Your Mark Design and Graphics, spoke about the new website functionality and the power and importance of using social networking to market the FISHNET group and member?s businesses online. The issue of social networking and internet marketing will be a reoccurring topic of discussion during the next few months.

Source: http://fishnetbiz.net/nj-chapter-september-breakfast-meeting-recap/

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Saturday, September 15, 2012

Home Based Business Patrick Willis Jersey Information and facts ...

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Is Your Thyroid Killing Your Weight Loss & Energy? | System 10

Nothing can affect your energy, health and weight loss like low thyroid function. It drastically limits your get up and go and ages you well beyond your years. It can mean you are operating at 66% or 50% of your normal power ? mentally and physically!

For those losing weight it can make it almost impossible because you burn 400 or 500 calories less than normal per day. Indeed it can limit or stop your weight loss no matter how much dieting or exercise you do. And the under-eating of poor diets makes the situation drastically worse.

Thyroid hormones affect the output of virtually every cell in the body from head to toe. Low thyroid can be at the root cause of depression. It can slow your digestion and cause constipation. It affects energy production, fertility and sex drive. It of course causes weight gain. It stresses the body and can greatly contribute to stomach fat. In our hurried and stressed lifestyle the thyroid is one of the most beaten up glands of all!

Unfortunately current blood testing helps very little. The hormones typically tested (TSH and T4) do not give enough information. We should at the very least be testing the T3 hormone too! The ranges of ?normality? are also too wide and allow a lot of people go undiagnosed. Many people who pass blood tests still have multiple signs of low thyroid function including ? very low energy, constant fatigue, poor blood circulation, feeling unnaturally cold, slow bowel function, poor skin and hair loss.

There are a huge number of people out there feeling very unwell with ?subclinical? thyroid i.e. not medically diagnosed. Certainly aging, pregnancy, poor lifestyle habits (smoking, excess sugar and alcohol), illness and over medication lower thyroid function and stress seriously lowers it.

So important is your thyroid that everyone can do with giving it a little bit of help and tlc! For some people this will transform their whole existence. Through good food, great nutrition and precise exercise we work on building everyone?s thyroid up naturally. We want to restore it back to as close to its best function as possible. The results are truly amazing not just in how you feel mentally and physically but how you look and the amazing weight and shape you can get back to.

?So if you are struggling with your weight, energy, health and your zest for life then let us turn back the clock for you. You have everything to gain and nothing to lose! System 10 is the only plan Worldwide that precisely combines the 3 keys ? diet, exercise and metabolism correction for your easiest and best weight loss ever and to help restore your energy and health back to better levels. Ph. 1890 510 610 today for a consultant near you! ? ? ?

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By David McDonagh. Dietician, Fitness Trainer & Motivation Coach. Creator of System 10 Precision Weight Loss.

www.system10weightloss.com

?

Posted in Info & Tips

Source: http://www.system10weightloss.com/is-your-thyroid-killing-your-weight-loss-energy/

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Gas prices, cars push US retail sales up 0.9 pct. | Long Island ...

by The Associated Press
Published: September 14, 2012
Tags: car sales, consumer spending, gas prices, Retail, retail sales, U.S. Commerce Department

U.S. retail sales rose in August from July because consumers paid higher gas prices and bought more cars and trucks. They were more cautious elsewhere, suggesting the weak economy has made many selective about spending.

Retail sales increased a seasonally adjusted 0.9 percent, the Commerce Department said Friday. Gas station sales jumped 5.5 percent, the most in nearly three years and a reflection of sharp price increases. Demand for autos increased 1.7 percent.

Outside those categories, sales rose only 0.1 percent. That?s below July?s 0.8 percent gain. Sales at general merchandise, clothing and electronic stores fell. Sales at grocery stores, sporting goods stores and online retailers were unchanged.

Gasoline sales are heavily influenced by price, and auto sales represent major purchases. Excluding those categories offers more clarity on consumers? willingness to spend.

?This has to go down as a weak report,? said Paul Dales, senior U.S. economist at Capital Economics. ?Most of the spending in August was on products that households have to buy, such as gasoline, not items they like to buy, such as new TVs.?

The retail sales report is the government?s first look each month at consumer spending, which drives roughly 70 percent of economic activity. Consumer spending has increased at a slow pace this year. That has dragged on the economy and kept businesses from hiring.

Higher gas costs also drove up consumer prices by the most in three years, the Labor Department said in a separate report. But excluding energy prices, inflation was mild.

Consumer prices rose 0.6 percent in August, the department said. Gas prices increased 9 percent and accounted for 80 percent of the increase. Outside food and energy, prices rose only 0.1 percent.

Overall consumer prices have increased 1.7 percent in past year. That?s well below the Federal Reserve?s inflation target.

Lower inflation will allow the Fed to stick with programs announced Thursday aimed at lifting the economy. If the Fed were worried that prices are rising too fast, it might have to raise interest rates.

On Thursday, the Federal Reserve said it would purchase $40 billion of mortgage-backed securities a month until the economy and job market show signs of steady improvement. Fed officials also said they would keep short-term interest rates low, even after the acceleration of any economic recovery.

Rising gas prices could make consumers more cautious about spending in the coming months. Gas prices averaged $3.87 a gallon nationwide on Friday, 16 cents higher than a month ago and just 7 cents below the 2012 average high.

Automakers earlier this month reported the best sales in three years, after seeing rising demand for pickup trucks.

The government?s retail sales data contrasted with reports from the nation?s largest retail chains. Many said things picked up in August, driven partly by back-to-school purchases. Sales at 18 retail chains rose last month by the most since March.

Sales at Target rose 4.2 percent and increased 5.1 percent at Macy?s. Gap Inc. posted a 9 percent jump in sales.

Employers added only 96,000 jobs last month, below the 141,000 added in July and far below the average gains of 226,000 in the first three months of the year.

The unemployment rate fell to 8.1 percent from 8.3 percent, but only because the number of people in the work force shrank.

The economy is growing too slowly to spur greater job gains. The economy expanded at a 1.7 percent annual pace in the April-June quarter. That?s down from 2 percent in the first quarter and 4.1 percent in the final three months of last year.

More breaking news


Source: http://libn.com/2012/09/14/gas-prices-cars-push-us-retail-sales-up-0-9-pct/

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Friday, September 14, 2012

How the video games industry is faring

Companies in the video games business have been reporting earnings for the most recent quarter. Here's a look at reports and results for selected companies that make or sell video games.

? July 12: NPD Group reports that U.S. retail sales of video game hardware, software and accessories fell 29 percent in June to $700 million. It's the seventh consecutive month of decline. Sales of console and portable software ? the video games themselves ? fell 29 percent from a year earlier, while sales of hardware fell 45 percent. Sales of accessories grew 4 percent. Excluded are sales of used games and rentals as well as digital and social-network spending. The top-selling game was "Lego Batman 2: DC Super Heroes," from Time Warner Inc.'s Warner Bros. Interactive.

? July 19: Microsoft Corp. says it sold 1.1 million Xbox 360 consoles, down from 1.7 million a year earlier, in what it calls a soft console market. Membership in its Xbox Live service increased more than 15 percent.

? July 25: Nintendo Co. says it sold 710,000 Wii units in the April-June quarter, down from 1.56 million a year ago. Nintendo is coming out with a successor, the Wii U, this year. It is forecasting 10.5 million units for the full fiscal year, which ends in March 2013.

? July 31: Video game publisher Electronic Arts Inc. reports a wider net loss and lower revenue in its latest quarter, but results are largely in line with expectations. It also announces a stock buyback of up to $500 million.

Take-Two Interactive Software Inc., another game publisher, says its loss in the latest quarter was much bigger than expected, because sales of "Spec Ops: The Line" and "Max Payne 3" were not as high as the company hoped.

? Aug. 2: Sony Corp. says sales fell about 15 percent, largely because of lower sales of the PlayStation 3 and the PlayStation Portable devices and the games that go with them. The decline was partly offset by the new PlayStation Vita, which went on sale in December in Japan and in the U.S. and Europe in February.

Video game publisher Activision Blizzard Inc. says net income dropped because of lower revenue from games. But adjusted results ? the more closely watched figure ? easily surpassed Wall Street's expectations and were much higher than a year ago.

? Aug. 6: Video game publisher THQ Inc. says revenue fell in the latest quarter, but adjusted results beat Wall Street's expectations as the company plan to reshape its business advanced. THQ is changing its focus to its core gaming business that includes popular wrestling and action-adventure video games such as "WWE" and "Darksiders." As part of that, it exited its traditional kids' licensed game business, trimmed its product line and streamlined operations. The process, however, is still ongoing.

? Aug. 7: The Walt Disney Co.'s interactive games division saw revenue fall 22 percent to $196 million as there were fewer significant titles compared with a year ago.

? Aug. 9: NPD says retail sales of new video game hardware, software and accessories fell for the eighth straight month in July. Overall sales fell 20 percent to $548.4 million. Sales of consoles and portable software ? the video games themselves ? fell 23 percent, while sales of hardware fell 32 percent. Accessories sales rose 8 percent. "NCAA Football 13" from Electronic Arts Inc. was the month's top seller.

? Aug. 16: GameStop Corp., the world's biggest video game retailer, reports a 32 percent decline in its quarterly income as sales slowed because not enough new games came out to draw in customers. Revenue fell 11 percent to $1.55 billion, short of Wall Street's $1.61 billion estimate.

? Sept. 5: Zynga Inc. releases a sequel to "FarmVille," hoping people will still play games on Facebook and computers as attention turns to mobile devices.

? Sept. 6: NPD says U.S. retail sales of new video game hardware, software and accessories fell for the ninth straight month in August. Overall sales fell 20 percent to $515.6 million. But one analyst notes that it was hardware that dragged on the month, while software sales dipped just 9 percent. "Darksiders II" was the month's top-selling game.

? Thursday: Nintendo Co. says its new Wii U game machine will go on sale in the U.S. on Nov. 18, starting at $300. It also announces an entertainment component called Nintendo TVii. The service collects all the ways users have to watch movies, TV shows and sports, such as through cable TV, Hulu and Netflix.

Source: http://news.yahoo.com/video-games-industry-faring-225521741.html

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How your cell phone wrecks your relationships ? even when you're not using it

U.K. researchers discover that the mere presence of a nearby phone can dramatically affect the way you feel about the person sitting in front of you

It's understandably tempting to play with your shiny new iPhone when you're out for dinner. But new research suggests that you don't even have to shower attention on your smartphone to sour your relationship with your dinner mate; in fact, just leaving your phone on the table ? untouched ? can do interpersonal damage. Here, a brief guide to the research, and why, for the umpteenth time, you should really consider keeping your phone in your pocket:

What happened in these studies?
Researchers Andrew K. Przybylski and Netta Weinstein of the University of Essex in Britain wanted to see if the mere presence of a phone could affect interpersonal connections. In one experiment, they placed two strangers together in a private booth and asked them to discuss a "moderately intimate topic" (something that had happened to them in the last month, for example) for 10 minutes. The pair sat in two chairs facing each other. Off to the side, not directly in their line of vision, was a desk. Sometimes the desk had a notebook on it. Other times it had a cell phone. After the chat, participants were asked to complete questionnaires about the closeness they experienced with their new pal.

SEE MORE: Boudoir photography: The divisive new wedding trend

What did they find?
On average, people who didn't have a cell phone lurking nearby experienced feeling closer and more connected to the stranger they just chatted with. Their curiosity piqued,?Przybylski and Weinstein decided to set up?a slightly different experiment.

What did the researchers do next?
They employed the same setting, but this time, they asked strangers to discuss either a "casual topic" (their thoughts and feelings about something like plastic trees) or a "meaningful topic" (their most important life events of the past year). Again, participants were given 10 minutes to chat, with either a cell phone or notebook on a nearby desk. At the end, they filled out questionnaires about "relationship quality, their feelings of trust, and the empathy they had felt from their discussion partners," says Helen Lee Lin at Scientific American.?

SEE MORE: Morning-after photos: The latest sexy wedding trend

And the results?
A cell phone's presence had no adverse effect on strangers discussing a casual, meaningless topic. But when a cell phone was near a pair discussing something meaningful, they reported feeling less trust in their their partners, and felt the person who sat across from them was less empathetic overall. "Thus, interacting in a neutral environment, without a cell phone nearby, seems to help foster closeness, connectedness, interpersonal trust, and perceptions of empathy," says Lin ? "the building-blocks of relationships."

Why are phones such a distraction?
The research team has a few ideas. Among them: While the increasing sophistication of phones certainly make the gadgets more diverting ? with games, apps, and social media all just a few taps away ? the gadgets also subconsciously signal a person's wider network of connections. The mere presence of a wired-up smartphone is a reminder that its owner knows lots of people, and chats, texts, and Facebooks with them on that phone ? even if it's not happening right at that moment. That inhibits?feelings of intimacy you'd otherwise get when you're sitting face-to-face with someone. The lesson? "Put your cell away when you're chatting with your partner or friend," says Diana Villbert at Care 2, "before your only companionship is Angry Birds."

SEE MORE: Semen: Nature's antidepressant?

Sources: Care 2, New York Daily News,?Scientific American

View this article on TheWeek.com Get 4 Free Issues of The Week

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Source: http://news.yahoo.com/cell-phone-wrecks-relationships-even-youre-not-using-114500089.html

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Thursday, September 13, 2012

Russian Prime Minister Medvedev says Pussy Riot should be freed

MOSCOW (Reuters) - Russian Prime Minister Dmitry Medvedev said on Wednesday he thought that three female members of punk band Pussy Riot who were sentenced to two years in jail last month for a political protest in a Moscow cathedral should be freed.

Medvedev, who was president for four years until May, appeared to be trying to disassociate himself from the jail terms which were condemned as excessive by the West and rights groups at home, as well as by liberal Russians.

When president, Medvedev styled himself as a liberal reformer, and though he handed the presidency back to Vladimir Putin he has made it clear he wants to remain in politics and perhaps even return to the presidency one day.

The three band members - Nadezhda Tolokonnikova, Maria Alyokhina and Yekaterina Samutsevich - were convicted of hooliganism motivated by religious hatred on August 17 after belting out a profanity-laced song criticizing Putin on the altar of Moscow's main cathedral in February.

They have been in jail since March and their appeal is due to start being heard on October 1.

"The prolongation of their incarceration in the conditions of jail seems to me to be unproductive," Medvedev said in televised remarks. "A suspended sentence, taking into account time they have already spent (in jail), would be entirely sufficient," he added.

However, Medvedev criticized the women, saying he was "sickened by what they did, by their looks, by the hysteria which followed what had happened".

He said prison is "very, very strict" punishment as a rule.

Medvedev emphasized he was expressing his personal view only and was not seeking to influence the case.

The band members had faced up to seven years in prison, but Putin said during the trial that they should not be judged "too harshly" and prosecutors subsequently requested three-year sentences; they were sentenced to two years each in the end.

In a television interview last week, Putin declined to comment on whether he believed the sentences were fitting, saying he was not interfering in the case.

But he suggested the band had forced its "indecent" name into public discourse and said abuses committed against the Russian Orthodox Church and other faiths in the Soviet era meant "the state is obliged to protect the feelings of believers".

(Reporting by Gleb Bryanski; Editing by Andrew Osborn)

Source: http://news.yahoo.com/russian-prime-minister-medvedev-says-pussy-riot-freed-165732162.html

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Phoenix-area rental homes a red-hot commodity

by Rob O'Dell and Catherine Reagor - Sept. 12, 2012 11:28 PM
The Republic | azcentral.com

Crowds of people swarming open houses. Multiple bids on properties from desperate home seekers. Palpable fear over losing the "right" place to a ravenous market.

• Map: Metro Phoenix rental market

Sounds like a typical day in metro Phoenix's housing market, where buyer demand exceeds the supply of homes for sale.

But this frenzy is focused on houses for rent.

In the Valley's most popular communities, desperate renters are submitting applications for multiple single-family homes to secure a place to live. Some would-be renters are dedicating as much as 20 hours a week to finding a new home. And when they find the right place, some feel pressure to offer much higher than the listed rent.

Greg Gale, a senior loan officer for Nova Home Loans, had only three weeks in August to find a new home. He launched a full-court press.

Gale applied to rent four properties, losing one after being a day late. He later found the property he wanted -- a 4,600-square-foot home in north Scottsdale -- and drafted a cover letter for his application, including his personal story and a promise to treat the house like his own. He included pictures of his children.

Gale admits he "pulled all the heartstrings" and believes it helped him get the house.

The unprecedented demand for rentals is fueled by former homeowners whose houses were foreclosed on or sold in short sales and now need a place to live. Some of them can no longer qualify to buy a home. For others, the housing bubble sullied the aura of owning a home.

In addition, new residents are migrating to the area for work. And members of households who had lived together out of financial necessity during the downturn are striking out on their own as the economy improves.

With the trend showing no sign of slowing, more investors than ever are buying homes to rent. Popular areas such as central and north Phoenix, south Scottsdale, Glendale, central Tempe, Chandler and Gilbert are hot spots for rentals.

Multiple indicators show demand for rentals has never been higher:

More rental contracts were signed in June and July than in any other months in the past decade, according to the Arizona Regional Multiple Listing Service.

The percentage of single-family homes purchased to be rented out hit a record 32 percent in July, more than triple the typical rate, said Mike Orr, a real-estate analyst at Arizona State University.

In July, the average rental home was empty for only 38 days, tied for the shortest period in 12 years, Orr said.

The vacancy rate for big apartment complexes recently hit an almost six-year low as of June 30, according to commercial broker Marcus & Millichap.

"It's a crazy rental market right now," said Liza Asbury of Realty One Group. "There are multiple offers for properties. If it (the home) is nice, it is definitely going fast."

One renter Asbury represented lost out on a high-end home in Paradise Valley because a competitor bid $400 more a month than the listed rent.

Number of renters growing

The biggest factor in the hot rental market is the number of people who have experienced a foreclosure or short sale and can't qualify to purchase a home.

Brett Nadler and Shelly Johnson are new to the rental-home market. Johnson was living in an apartment after a recent foreclosure.

A new couple, they have been searching for a four- or five-bedroom house since the end of May, hoping they could find a home to accommodate them, Johnson's two sons and Nadler's son and daughter. But it has been challenging.

In late August, they attended an open house at Power Ranch in Gilbert, hoping to get into a neighborhood where Johnson's kids could continue attending the same elementary school.

"Everything rents really quickly," Nadler said.

"You find a house on Craigslist, and the next day, the posting is gone," Johnson said.

Ana Garcia is looking to rent for the first time. In fact, she was a landlord herself, owning 16 low-income properties in Mesa. But she lost the houses to the bank last year, and her own home in east Mesa was foreclosed on this year.

She's living in her foreclosure home but needs to find a new place quickly. She said it's hard work to find a nice place. "By the time you realize it, they are gone," she said.

The properties that stay on the market are often dirty or have other issues. She recently saw a property that had termites, but the owners refused to get it treated because they didn't feel they had to in order to rent it out.

A diabetic, Garcia said the situation has created a sense of panic that has aggravated her health problems.

"It's there 24/7," Garcia said of the anxiety. "Your health suffers."

Most-popular areas

Both homebuyers and renters are flocking to the same parts of metro Phoenix. Areas near freeways, shopping centers and jobs are drawing the most new residents.

In the central Tempe ZIP code 85282, an area south of ASU and flanked by freeways, the typical rental home stays vacant for less than 22 days.

Rentals are also scarce in several central Phoenix and south Scottsdale ZIP codes. In 85012, a north-central Phoenix neighborhood, there are only 13 homes for rent and 37 for sale. A year ago, double that many homes were on the market in the neighborhood, stretching up Central Avenue to Glendale Avenue.

In ZIP code 85031, an affordable west Phoenix Maryvale neighborhood, there are only 12 homes for rent and 18 for sale.

In Gilbert's 85298 ZIP code, where many of the area's new homes are selling, there are only 28 homes for rent, and the average rental house leases in 34 days. The typical house rents for less than $850.

Many of the communities with the highest rents are taking the longest to rent.

North Scottsdale's 85266 ZIP code, which encompasses an area stretching north to Carefree, has the longest average time to lease a home of any sizable ZIP code: 138 days.

In Paradise Valley, ZIP code 85253, it's taking a landlord more than 100 days to find a tenant. There are more than 250 homes for sale in the upscale enclave and 62 for rent. Paradise Valley has metro Phoenix's priciest homes and rentals. The average rent for one the area's mansions is almost $4,000 a month.

Renting is the new buying

The demand for rentals has spawned a new phenomenon: Some landlords are holding weekend open houses to show off properties to several prospective tenants at once.

The events are often crowded with desperate home seekers.

Sean Badding, who owns five rental properties in the Valley, had more than 30 people attend his open house in July for a two-bedroom, one-bath home at the edge of the Encanto-Palmcroft Historic District that he offered for rent at $1,050 a month.

Twelve people submitted rental applications, Badding said, and he rented the property immediately.

"The location makes the biggest difference. A prime location, whether it is rent or sale, allows you to get it off the market as soon as possible," he said.

Chris Doyle began advertising his 2,000-square-foot, four-bedroom, 21/2-bathroom house at Power Ranch in Gilbert for $1,195 a month on Aug. 22. He had eight calls in the next few days, and four families showed up at an open house on Aug. 26.

He got that traffic despite not including the address in his advertisement or erecting a "for rent" sign in front of the home until minutes before the open house. Doyle said a yard sign will usually bring as much traffic as ads on Craigslist or elsewhere, and many landlords advertise with yard signs only because demand is so high.

Doyle raised the monthly rent on the home by $100 a month, but it didn't dampen interest.

"I saw the demand was there," Doyle said.

Desperate renters

Renters are dedicating as many as 20 hours a week to looking for the right home, and their searches can still take months, numerous renters and real-estate agents said.

Gale, who rented the house in north Scottsdale, said his wife, a stay-at-home mom, would gather listings from Internet searches or their real-estate agent and start driving to as many properties as she could get to in a day.

"There was a week where she went out every day or twice a day," Gale said. "It's literally a frenzy. You pull up to a house, and there are two other people there."

Carmen Mioni searched for nearly four months for just the right townhouse in north-central Phoenix with a patio for her large dog. She looked at more than 75 properties on the Internet and visited 10 in person. Still, she couldn't find exactly what she wanted and signed a lease on a less-than-ideal townhouse -- the patio was too small for the dog.

"It was the best option I had because I was running out of time," Mioni said. "I just went with it because there wasn't going to be another place."

Mioni said she also had to sign a longer lease than she wanted -- 18 months instead of 12 -- to get her rent down to $1,000 a month, where she needed it.

"It's totally frustrating because your options are limited," Mioni said.

Landlords' market

Investors are responding to the demand and to home prices that are still well below boom levels.

In July, nearly one in three homes purchased was bought to be used as a rental, the highest percentage ever, ASU's Orr said.

Typically, the percentage of homes bought to rent is 8 percent to 10 percent, Orr said. During the past two years, it ranged from 20 percent to 25 percent before hitting 32 percent in July.

For those who have the cash to buy, there is a historic spread between how much it costs to finance a home and monthly rents, so investors who buy at the right price can rent the house right away for more than the cost of a mortgage, taxes and insurance, while at the same time getting generous tax breaks.

The rental rates haven't risen much despite the high demand -- data show rents flat or rising slightly -- but the price of housing has dropped 60 percent from the peak and only now is beginning to recover, Orr said. As a result, the "ratio has changed in favor of the landlord," he said.

Kathy Karneth, who owns an investment property in Tempe and has recently flipped several houses, said her biggest problem is finding good deals on houses with the inventory so low. She will soon begin direct-mailing residents in certain Tempe neighborhoods -- she buys only in Tempe -- hoping to find a struggling homeowner willing to strike a deal before the property is formally listed on the market.

"It's a very strong market," said Alan Langston, executive director of the Arizona Real Estate Investors Association. "Something else is wrong with the property if it's not rented immediately."

Source: http://www.azcentral.com/news/articles/2012/09/04/20120904phoenix-area-rental-homes-red-hot-commodity.html

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7th-generation iPod nano hands-on!

7thgeneration iPod nano handson!

Not to be outdone by a refreshed iPod touch (and, let's face it, a new iPhone), Apple also shot out a 5.4mm-thick iPod nano today -- that's 38 percent thinner than the one it replaces. We just got our hands on the newest, tiniest music player outside of Apple's product launch today, replete with a 2.5-inch multitouch panel and a familiar Home button. As you'd expect, the enlarged display is hugely beneficial. While there's no bona fide version of iOS on here, the stripped-down variant seems sufficient for handling media alone. As if the ability to watch widescreen video wasn't enough, fitness gurus are also apt to take notice -- inbuilt support for Nike+ gear, along with Bluetooth, make this one potent device.

The Lightning connector seems to make a lot of sense here, given the dearth of real estate along the bottom, but somehow the company squeezed a big enough battery in here to net some 30 reported hours of battery life. In playing with it, we found screen transitions to be adequately smooth, and video playback was surprisingly enjoyable to watch.

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7th-generation iPod nano hands-on! originally appeared on Engadget on Wed, 12 Sep 2012 15:15:00 EDT. Please see our terms for use of feeds.

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Wednesday, September 12, 2012

iOS 6 coming to iPhone 4S, 4, 3GS, new iPad, iPad 2 and iPod Touch on September 19th

We know what we're getting from iOS 6 and won't have to wait long for it. Apple's new mobile OS will land on existing phones, tablets and media players on September 19th -- a week from today. As was mentioned when we first saw iOS 6, the cut-off appears to be the iPhone 3GS, while tablets starting from the second iteration will be able to access Apple's new feature set.

Check out our liveblog of Apple's event to get the latest news as it happens!

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iOS 6 coming to iPhone 4S, 4, 3GS, new iPad, iPad 2 and iPod Touch on September 19th originally appeared on Engadget on Wed, 12 Sep 2012 14:03:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/09/12/ios-6-coming-to-iphone-4s-4-3gs-new-ipad-ipad-2-and-ipod-tou/

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Report: Teacher shortage looms for California

By Sharon Bernstein, NBCLosAngeles.com

California is facing a shortage of qualified teachers and principals for its public schools, according to a?long-anticipated report released this week.

Fewer aspiring teachers are enrolling in credentialing programs, and jobs in key subject areas -- including special education and mathematics -- are already going unfilled for lack of applicants, the state Task Force on Educator Excellence said.

Those who seek to teach face a working life that is underpaid, unstable and, in the case of would-be administrators, highly political. Working conditions, the group said, are "highly inequitable," with the least experienced and lowest paid teachers generally sent to work in the most difficult conditions.


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?Ours is a profession under siege,? State Superintendent of Public Instruction Tom Torlakson wrote in a letter introducing the report. ?At the very moment the need for outstanding educators seems most urgent, talented teachers are being displaced by budget cuts and discouraged by trying working conditions.?

During the school year of 2009-2010, California issued just 16,151 credentials to new teachers ? a 40 percent drop over 2003-2004. During the ten years ending in 2010, the number of students enrolled in teacher preparation programs dropped by half, the report said.

While it is true that teachers have been laid off in the state, many are not choosing to seek new jobs in the profession, the report said.

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Shortages persist, the task force said, in educational fields including special education, mathematics, physical sciences and in the instruction of students who are still learning English.

These shortages are looming even as the state is trying to improve education for California children.

To that end, the task force recommended stepping up mentoring and training programs for new and experienced teachers, and reinstating long-abandoned funding that provided paid time for teachers to prepare lessons and curriculum.

The group also encouraged increased requirements ? as well as more mentoring and support ? for those who wish to become principals.

Watch the most-viewed videos on NBCNews.com

Recent efforts to install accountability measures for teachers and low-performing schools also came under fire in the report.

Such measures ? which include efforts to tie teacher performance evaluations to student test scores ? may help to measure performance, but cannot provide teachers with the tools they actually need to improve instruction, the task force said.

?High-stakes testing without investments in school capacity cannot improve education,? the report said. ?In fact, this dangerous combination has driven many accomplished educators out of the profession and, in some cases, caused more harm than good.?

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Source: http://usnews.nbcnews.com/_news/2012/09/11/13809187-report-teacher-shortage-looms-for-california?lite

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Many questions arise about anti-Islam filmmaker

Protesters destroy an American flag pulled down from the U.S. embassy in Cairo, Egypt, Tuesday, Sept. 11, 2012. Egyptian protesters, largely ultra conservative Islamists, have climbed the walls of the U.S. embassy in Cairo, went into the courtyard and brought down the flag, replacing it with a black flag with Islamic inscription, in protest of a film deemed offensive of Islam. (AP Photo/Mohammed Abu Zaid)

Protesters destroy an American flag pulled down from the U.S. embassy in Cairo, Egypt, Tuesday, Sept. 11, 2012. Egyptian protesters, largely ultra conservative Islamists, have climbed the walls of the U.S. embassy in Cairo, went into the courtyard and brought down the flag, replacing it with a black flag with Islamic inscription, in protest of a film deemed offensive of Islam. (AP Photo/Mohammed Abu Zaid)

CORRECTS NATIONALITY OF FILMMAKER - An Egyptian woman holds a black flag with Islamic inscription in Arabic that reads, "No God but Allah, and Muhammad is his prophet," in front of the U.S. embassy in Cairo, Egypt, Wednesday, Sept. 12, 2012, as part of widespread anger across the Muslim world about a film ridiculing Islam's Prophet Muhammad. A man identifying himself as Sam Bacile, a 56-year-old California real estate developer, said he wrote, produced and directed the movie. He told the AP he was an Israeli Jew and an American citizen. But Israeli officials said they had not heard of Bacile and there was no record of him being a citizen. (AP Photo/Nasser Nasser)

CORRECTS NATIONALITY OF FILMMAKER - Egyptian soldiers stand guard in front of the U.S. embassy in Cairo, Egypt, Wednesday, Sept. 12, 2012, as part of widespread anger across the Muslim world about a film ridiculing Islam's Prophet Muhammad. A man identifying himself as Sam Bacile, a 56-year-old California real estate developer, said he wrote, produced and directed the movie. He told the AP he was an Israeli Jew and an American citizen. But Israeli officials said they had not heard of Bacile and there was no record of him being a citizen. Arabic on the wall reads, "anyone but God's prophet." (AP Photo/Nasser Nasser)

CORRECTS NATIONALITY OF FILMMAKER - An Egyptian soldier stands guard in front of the U.S. embassy in Cairo, Egypt, Wednesday, Sept. 12, 2012, as part of widespread anger across the Muslim world about a film ridiculing Islam's Prophet Muhammad. A man identifying himself as Sam Bacile, a 56-year-old California real estate developer, said he wrote, produced and directed the movie. He told the AP he was an Israeli Jew and an American citizen. But Israeli officials said they had not heard of Bacile and there was no record of him being a citizen. Arabic on the wall reads, "anyone but God's prophet." (AP Photo/Nasser Nasser)

LOS ANGELES (AP) ? The man behind video exerpts from an anti-Muslim movie that provoked mobs in Egypt and Libya said Wednesday that he has gone into hiding. But doubts rose about the man's exact identity amid a flurry of false claims about his background and role in the purported film.

The filmmaker, who identified himself in a telephone interview with The Associated Press as Sam Bacile, said he is an Israeli-born, Jewish writer and director of "Innocence of Muslims." Bacile was the name used to publish excerpts of the movie online as early as July 2.

But some key facts about Bacile's background and role in the film crumbled Wednesday as a Christian activist involved in the film project said that Bacile was a pseudonym, that he was not Jewish or Israeli, and that a group of Americans of Mideast origin collaborated on the film. Officials in Israel also said there was no record of Bacile as an Israeli citizen.

Doubts mounted as well about the provenance of the film, "Innocence of Muslims." Several Hollywood and California film industry groups and permit agencies said they had no records of the project. Only an employee at a faded Hollywood movie theater confirmed that an entire version of the film had staged a brief run several months ago.

All that currently exists of the film are about 13 minutes of excerpts on YouTube, in English and Arabic language versions. While the excerpts were still viewable online in the U.S. on Wednesday, they vanished from the Web in Egypt. Cairo residents who tried to view the YouTube site instead got a warning that "this content is not available in your country due to a legal complaint."

Protesters apparently angered over the film burned down the U.S. Consulate Tuesday in the eastern Libyan city of Benghazi. Libyan officials said Wednesday that Ambassador Chris Stevens and three other embassy employees were killed during the mob violence, but U.S. officials now say they are investigating whether the assault was a planned terrorist strike linked to Tuesday's 11-year anniversary of the Sept. 11 attacks.

In his brief interview with the AP, the man who identified himself as Bacile defiantly called Islam "a cancer," and said that he intended the film to be a provocative political statement condemning the religion.

But several facts Bacile provided about himself soon proved false or questionable.

Bacile told AP he was 56, but identified himself on his YouTube profile as 74.

A Riverside, Calif., Christian activist who said he was a consultant and worked with Bacile on the film told The Atlantic Monthly on Wednesday that Bacile's name was a pseudonym, and that he was not Jewish or Israeli. The activist, Steve Klein, said that behind the film were Americans who had lived in several Mideast countries.

"Nobody is anything but by an active American citizen," Klein told the Atlantic. "They're from Syria, Turkey, Pakistan, there are some that are from Egypt. Some are Copts but the vast majority are evangelical."

In an interview Tuesday with the AP, Klein said the filmmaker is concerned for family members who live in Egypt. Bacile declined to confirm that suggestion. Klein did not return phone messages to the AP on Wednesday.

Klein told the AP that he promised to help Bacile make the movie but warned him that "you're going to be the next Theo van Gogh." Van Gogh was a Dutch filmmaker killed by a Muslim extremist in 2004 after making a film that was perceived as insulting to Islam.

"We went into this knowing this was probably going to happen," Klein said.

Bacile told the AP he is a real estate developer and an Israeli Jew. But Israeli officials said they had not heard of him and there was no record of him being a citizen. They spoke on condition of anonymity because they are not permitted to share personal information with the media.

The name Bacile also does not appear in searches of California state licenses, including the Department of Real Estate.

Directors' and producers' groups in Los Angeles said they had no record of Bacile and California's state film commission said no permits had been issued to Bacile or "Innocence of Muslims." But officials added that films can easily be made on a shoestring, without permits and under the radar of authorities and film industry watchdogs.

"There's no universal registry where you can tell for sure this is legitimate film," said Chris Green, a spokesman with the Producer's Guild of America.

The only sparse evidence indicating that an entire version of "Innocence of Muslims" was filmed beyond its 13.5-minute trailer came in comments from an employee of the Vine Theater, a Hollywood Boulevard theater that was padlocked on Wednesday. The theater employee, who declined to identify himself, said that a version of "Innocence of Muslims" ran briefly several months ago at the theater and that a man whose first name was Sam had brought the film to the theater.

In his earlier interview with AP, the man who identified himself as Bacile said that the film had run for a day at a mostly-empty Hollywood theater.

"This is a political movie," Bacile told the AP. "The U.S. lost a lot of money and a lot of people in wars in Iraq and Afghanistan, but we're fighting with ideas."

Bacile said he believes the movie will help his native land by exposing Islam's flaws to the world.

"Islam is a cancer, period," he said repeatedly, his solemn voice thickly accented.

The two-hour movie, "Innocence of Muslims," cost $5 million to make and was financed with the help of more than 100 Jewish donors, said Bacile.

The film claims Muhammad was a fraud. The trailer, posted in an original English version and another dubbed into Egyptian Arabic, shows an amateur cast performing a wooden dialogue of insults disguised as revelations about Muhammad, whose obedient followers are presented as a cadre of goons.

It depicts Muhammad as a feckless philanderer who approved of child sexual abuse, among other overtly insulting claims that have caused outrage.

Muslims find it offensive to depict Muhammad in any manner, let alone insult the prophet. A Danish newspaper's 2005 publication of 12 caricatures of the prophet triggered riots in many Muslim countries.

Though Bacile was apologetic about the American who was killed as a result of the outrage over his film, he blamed lax embassy security and the perpetrators of the violence.

"I feel the security system (at the embassies) is no good," said Bacile. "America should do something to change it."

Bacile's film was dubbed into Egyptian Arabic by someone he doesn't know, but he speaks enough Arabic to confirm that the translation is accurate. It was made in three months in the summer of 2011, with 59 actors and about 45 people behind the camera.

___

Braun reported from Washington. Associated Press writer Michael Blood contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-09-12-Egypt-Filmmaker/id-bd335c42109a4060ad0c972228901a6a

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Tuesday, September 11, 2012

Forgery fight gets boost from invisible barcode

1 hr.

Scientists?in the United States have made an invisible version of square modern barcodes using nanoparticles and fluorescent ink to help in the fight against counterfeiting.

Blocks of black and white Quick Response (QR) codes are increasingly common in marketing and can hold a hundred times more information than traditional barcodes. Smartphones can scan them in printed adverts to navigate to company websites.

Researchers have found out how to print them with inks that are only visible under laser light, giving them potential in the fight against fake banknotes and counterfeiting, which the OECD estimates costs the world economy more than $250 billion a year.

The invisible QR code, made by scientists at the University of South Dakota and South Dakota School of Mines & Technology, is made of tiny nanoparticles mixed into fluorescent ink, which can only be seen when illuminated with a near-infrared laser.

The process is known as "upconversion" where the nanoparticles absorb photons at a certain wavelength and then emit them at a shorter wavelength visible in normal light.

"We can also change our parameters to make it even more difficult to counterfeit, such as controlling the intensity of the upconverting light or using inks with a higher percentage of nanoparticles," said Jeevan Meruga, who led the research.

Once lit up with the laser, the code can be scanned with a mobile phone, but the technique allows deeper levels of security with the ability to conceal information that can only be read with a microscope.

The invisible codes can still be read after paper has been folded many times and can also be printed other materials, including glass and flexible plastic film, so they could be used for a variety of products vulnerable to faking.

The research was published in the academic journal Nanotechnology.?

(c) Copyright Thomson Reuters 2012. Check for restrictions at:?http://about.reuters.com/fulllegal.asp?

Source: http://www.nbcnews.com/technology/futureoftech/fight-against-forgery-gets-boost-invisible-nano-barcode-993358

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Sweet Shoppe Designs ? The Sweetest Digital Scrapbooking Site ...

Birthdays are always something I?ve tried to make very special for my daughters. ? I love to celebrate each of them individually to show my kids how special they are to me. ?For the past four years we have hosted my youngest daughter?s, Hannah, birthday party at our house during Labor Day weekend. ?We generally invite all of our family and friends ? which means we start getting ready in June for the early September celebration (you know ? new mulch, fix up the landscaping, clean the guest room, all sorts of house projects we?ve put off for the last year). ?Well I decided that this year I wanted a break from that madness so I asked Hannah to find a place to host her birthday party. ?Now, Hannah is not your typical 9, turning 10 year old. ?She is more into building, video games, science, and sports versus tweeny girl kind of stuff. ?So finding something that suited her personality and her age proved to be a bit of an adventure. ? We spent weeks deliberating where to go, who to invite, figuring out what it would all cost and then changing our minds. ?So, while my kids were taking their summer vacation with my in-laws I came up with an idea that was sure to win my daughter?s heart.

We decided to allow Hannah to pick 3 friends to accompany here to Disney Quest in Orlando for the day. ?We live about an hour and half from Disney so I knew we were going to have to talk to parents to see who would allow their daughter to attend. ? After narrowing down our huge guest list we had a list of 5 potential girls to come with us. ?I challenged my daughter to pick girls that she really liked talking with at school or playing with at the Y so we could build some new relationships. ?(She?s going off to middle school next year and I am determined to help her learn how to grow some new friendships this year so that the transition is easier for her next year.)

So using my digiscrapping skills, I came up with the invites below ? which we handed out after I had already talked to each girl?s parents?. ?(I didn?t want to give a girl an invite and have them really want to go and then their parents not be comfortable with us driving them so far.)

Party planning ? We brainstormed on ideas for a good party favors and came up with giving each girl a plastic basket that they could bring in the car with them. ?Inside we provided the following: ?two little bags of chips for snack, ?lip gloss, ?a ring pop, a Crayola mini coloring pack that included some color sheets and markers, erasers that look like cassette tapes, 2 mini tubs of Play Doh, a Bath and Body Works hand sanitizer inside a glow in the dark holder (perfect for cleaning hands after playing games) and a glow stick necklace that Hannah beaded for each girl with black and glow in the dark beads. ?To have the favors match our Disney theme, Hannah helped me cut out Mickey heads using my Cricut. ?She then cut out each girl?s name using the Cricut and I glued them on using a Zig 2 way glue pen. This is how they turned out.

?

The big day arrive this past Saturday and after a lot of worrying if the girls would have a good time, would anyone get home sick, would everyone behave, etc. ?I have to say that I feel like the most blessed mom in the world! ?Remember: these were new friends she invited so I didn?t know these girls very well. ?All three of them had different personalities and none of them really knew each other and they all got along beautifully! Plus we ended up taking my older daughter Katie (13) with us (even though she said she didn?t want to go) and she ended up being the leader of pack with the girls in way that really worked well. ? So what did we do on our adventure? ?Here?s a few pictures to show you -

We left the house around 9:30 am and headed to Orlando. ?After picking up our tickets at a discount ticket broker we spotted a CiCi?s pizza which seemed like the perfect place to grab lunch before we started our gaming adventure. ?What?s better than pizza, pasta (salad for mom) and some brownies???? ?Here?s the girls spelling out CiCi?s by the sign (the birthday girl is the blonde one in the teal shirt).

Next we headed to Downtown Disney to start our gaming adventure. ?Before we went in a took a picture of each girl with Hannah and then a few group shots. ?The individual shots were for a final thank you gift I planned to make the next morning before the girls went home.

?

Once inside we had fun exploring each of the 5 floors. Here?s a few things we learned about Disney Quest:

We left Disney Quest at about 10:45 and drove back to Tampa. ?About 30 minutes in to the ride all the girls were fast asleep in the backseat. ?Of course, this was just a nap because when we got home they were all wide awake again. ?My husband and I left the girls downstairs with a movie, some popcorn and the TV remote and we finally fell in to bed for ourselves. ?It was such a fun day and I have to say that I?m soooo proud of my daughter. ?She has picked the nicest girls to be her friends. ?Which made the day even more sweet!

As I cooked breakfast Sunday morning, I also made these cute keychains for the girls to put on their backpacks. ?I thought it was a great way for them all to remember such a fun day! ?I got the key chains at the Dollar Spot at Target early in August. ?They were the cherry on top of a fantastic birthday!!!

Supplies used to make invites and key chains: ?Be Our Guest by Libby Pritchett

?

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Source: http://www.sweetshoppedesigns.com/index.php/2012/09/the-quest-for-birthday-adventure/

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[WATCH]: Jo Parry Step Aerobics Choreography Ideas

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Monday, September 10, 2012

Video: Study: OK to let babies cry it out

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Source: http://video.msnbc.msn.com/nightly-news/48978721/

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Expanding database enables discoveries in emerging field of metabolomics

ScienceDaily (Sep. 10, 2012) ? Over the last decade, metabolomics has emerged as the newest of the "omic" sciences (following genomics and proteomics) to provide comprehensive biochemical information about cellular metabolism. This new field has revealed that many of the chemicals involved in or produced through metabolism are currently unknown, but may play vital and previously unappreciated roles in human health and disease.

A major hurdle in profiling both unknown and known metabolic compounds ("metabolites") has been the scarce amount of reference data. But a team from The Scripps Research Institute has developed a massive, searchable online metabolite database that is transforming the field and being widely used in research on countless conditions including cancer and chronic pain.

The researchers describe the newly expanded database, called METLIN, and its potential benefits in the September issue of the journal Nature Biotechnology.

Getting Off the Beaten Path

Scientists once focused on only the major metabolic highways, well-known pathways such as glycolysis and the Krebs Cycle. New metabolomic studies have shown that other pathways and metabolites, however, also play critical roles in fundamental biological processes and the progression of disease.

"For decades biochemical studies have targeted only a handful of canonical metabolites, and comprehensive profiling has been mostly limited to genes and proteins," said Gary Patti, a former postdoctoral fellow at Scripps Research now an assistant professor at Washington University in St. Louis who helped develop the database. But now he says the new field of metabolomics has emerged with huge promise for medical and other advancements. "I think it's a really exciting time because the insights being provided by metabolomics are in some cases affecting the way in which we think about fundamental biochemistry," he said.

The sheer number and complexity of metabolites offer scientists a colossal challenge. While DNA studies of genes that code for proteins offer clues about how many proteins there are and their functions, there's no such map for metabolites -- which include a huge range of chemical types, from amino acids, carbohydrates, and steroids to large, complex fatty acids. No one knows how many metabolites there are in humans, though the number may well be over 100,000, and other organisms may have their own unique arrays.

Digging In

Metabolites can be isolated and analyzed from almost any biological specimen, including tissues, blood, urine, and tumors. The most sensitive technique for analyzing metabolites is mass spectrometry. By using cutting-edge mass spectrometric technologies, the molecular weight of thousands of metabolites can be measured within a few minutes. Previously, researchers might spend days combing databases and other sources of information to identify just one metabolite of interest.

"If you don't have a database like METLIN, the value of metabomic data would be very limited because each study would require manual searches and ultimately fail to culminate in enough reference data to arrive at conclusive metabolite identifications," said team leader Gary Siuzdak, a metabolomics expert at Scripps Research.

It was against this landscape that Siuzdak's group recognized the need for a consolidated and expanded metabolite database to meet the group's own needs as it struggled to understand key metabolic processes. Efforts to build such a resource began in 2004 and the database they dubbed METLIN was initially built upon slowly. Information was scarce and entered manually, sometimes after curating chemistry books manually for new structural information. Researchers in the lab would compete to see who could add the most in a week. Simultaneously, the lab also began cataloging experimental tandem mass spectrometry data on these compounds and established the first of such resources to provide structural information on metabolites that can be used to identify metabolites.

Over the past few years, determined to accelerate their work, group members gained major momentum largely by partnering with companies like Sigma, Cayman, ChromaDex, as well as labs at Scripps Research (Boger), University of California, San Diego (Gerwick), the Joint BioEnergy Institute (Berkeley), and now Washington University (Patti) to facilitate acquisition of more molecules on which to generate tandem mass spectrometry data.

More than 10,000 Metabolites

Now METLIN includes more than 60,000 compounds with detailed, high-resolution tandem mass spectrometry information on more than 10,000 metabolites, by far the largest in the world. And the Siuzdak group is far from done. "METLIN is still growing as we speak," said Ralf Tautenhahn, a senior research associate in Siuzdak's lab and first author of the paper. "It's a key tool for all our projects." Once a metabolite is identified, researchers can begin working out how it functions in the body and in disease.

A key benefit of the database is that it goes beyond basic molecular weight -- which might be the same for a range of different compounds. The tandem mass spectrometry data allows for a higher level of confidence in identifying these molecules from biological systems. This involves bombarding individual compounds with gas molecules, which causes them to break apart in unique ways. The weights of the resulting molecular fragments offer a sort of chemical signature for each metabolite that researchers can use to match unknowns more precisely.

Though you can search METLIN manually, the Scripps Research team has also developed software called XCMS Online that performs detailed automated searches. Users can input their own data and the coupled XCMS-METLIN system will come back with precise matches, or if there's no direct match, it will identify structurally similar metabolites. "It really does accelerate the whole process of discovering new molecules associated with diseases and research in many different areas," said Siuzdak.

Tapping the Potential

The Siuzdak team has already had major successes using the database. The researchers recently identified a metabolite that is associated with chronic pain when found in higher than normal levels. Finding ways to break down this metabolite or to prevent it from forming might lead to new treatment options for chronic pain sufferers.

Other projects are focused on cancer. While some researchers are looking for metabolites that might be present in the bloodstream as early indicators of cancer, Siuzdak's group is identifying metabolites involved in cancer's progression that might offer targets for new therapies. Patti's lab at Washington University is further investigating the role of metabolism in chronic pain and is also looking into metabolite roles in aging and drug addiction.

But public access means METLIN's reach stretches far beyond Scripps Research. "When we first started doing this, I was expecting a couple of hundred people in the world to use it," said Siuzdak. Instead, he and his colleagues were shocked to find users by the thousands exploring a huge range of topics. Some researchers are looking for metabolites produced after ingestion of drugs to aid in forensics work; others are interested in ways to detect signs of pesticide ingestion.

"What's really exciting about this is seeing that something we created is being so widely used," said Siuzdak, "It definitely makes us feel good to think that we've accelerated the progress of science and allowed a lot of other scientists to do things they wouldn't have been able to do otherwise."

This research was funded by the California Institute of Regenerative Medicine (TR1-01219), the US National Institutes of Health (R24 EY017540, P30 MH062261, RC1 HL101034, P01 DA026146, L30 AG0 038036), and the US Department of Energy (FG02-07ER64325 and DE-AC0205CH11231).

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The above story is reprinted from materials provided by Scripps Research Institute.

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Journal Reference:

  1. Ralf Tautenhahn, Kevin Cho, Winnie Uritboonthai, Zhengjiang Zhu, Gary J Patti, Gary Siuzdak. An accelerated workflow for untargeted metabolomics using the METLIN database. Nature Biotechnology, 2012; 30 (9): 826 DOI: 10.1038/nbt.2348

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/ly_znmo47LU/120910185757.htm

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